Professor Biochemistry and Molecular Biology

Professor

Biochemistry and Molecular Biology

RESEARCH OVERVIEW

Biochemistry and molecular biology, reproductive biology, fertilization, cell adhesion, cytoskeleton, egg, sperm, oocyte maturation, meiosis, contraception, infertility. 

 

Cell Biology | Cellular Stress and Cell SignalingDevelopmental and Stem Cell Biology

Selected Publications:

Mackenzie, A.C.L, Kyle, D.D., McGinnis, L.A., Lee, H.J., Aldana, N., Robinson, D.N., and Evans, J.P.  Cortical mechanics and myosin-II abnormalities associated with post-ovulatory aging:  Implications for functional defects in aged eggs. Mol. Human Reprod. 2016 PMID: 26921397.

Christianson, M.S., Gerolstein, A.L., Lee, H.J., Monseur, B.C., Robinson, D.N., and Evans, J.P. Effects of inhibition of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) on sperm incorporation and cortical tension in mouse eggs.  Mol. Reprod. Dev. 2016 PMID: 26781791. 

McGinnis, L.A., Lee, H.J., Robinson, D.N., and Evans, J.P.  MAPK3/1 (ERK1/2) and Myosin Light Chain Kinase in mammalian eggs affect myosin-II function and regulate the metaphase II state in a calcium- and zinc-dependent manner.  Biol. Reprod. 2015 PMID: 25904014.

Matthews, L.M. and Evans, J.P.  α-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytes.  Cell Cycle 2014 PMID: 24675883.

Kryzak, C.A., Moraine, M.M., Kyle, D.D., Lee, H.J., Cubeñas-Potts, C., Robinson, D.N., and Evans, J.P.  Prophase I mouse oocytes are deficient in the ability to respond to fertilization by decreasing membrane receptivity to sperm and establishing a membrane block to polyspermy.  Biol. Reprod. 2013 PMID: 23863404.

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