Professor Radiation Oncology and Molecular Radiation Sciences Oncology

Professor

Radiation Oncology and Molecular Radiation Sciences

Oncology

RESEARCH OVERVIEW

The particular interest of our lab is to understand the regulatory events that prevail in cancer cells, and detect and exploit cancer cell characteristics that could be used as basis of new cancer therapies. The approaches used in the laboratory are aimed to provide novel information on the regulation of cellular DNA damage and tumorigenesis pathways, to identify new targets for therapy, and to apply this knowledge to therapy efforts. The studies aim at a rapid transfer of findings arising from focused mechanistic studies into translational cancer research.

Cell Biology | Chemical Biology and Proteomics | Translational Research

Selected Publications:

Peltonen K, Colis L, Liu H, Jäämaa S, Zhang Z, Af Hällström T, Moore HM, Sirajuddin P, Laiho M. Small molecule BMH-compounds tha PubMed Central PMCID: PMC4221476.  

Bai B, Yegnasubramanian S, Wheelan SJ, Laiho M. RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs. PLoS One. 2014 PubMed PMID: 25203660.

Peltonen K, Colis L, Liu H, Trivedi R, Moubarek MS, Moore HM, Bai B, Rudek MA, Bieberich CJ, Laiho M. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell. 2014 PubMed PMID: 24434211.

Moore HM, Bai B, Boisvert FM, Latonen L, Rantanen V, Simpson JC, Pepperkok R, Lamond AI, Laiho M. Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. Mol Cell Proteomics. 2011 PubMed PMID: 21778410.

Jäämaa S, Af Hällström TM, Sankila A, Rantanen V, Koistinen H, Stenman UH, Zhang Z, Yang Z, De Marzo AM, Taari K, Ruutu M, Andersson LC, Laiho M. DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue. Cancer Res. 2010 PubMed PMID: 20978201.

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