Our group studies the immunological, hormonal, and genetic factors mediating sex differences, age-related changes, and the effects of pregnancy on infectious disease pathogenesis and vaccination. Using several model systems, including influenza, Zika, and malaria, we are uncovering the mechanisms mediating how females have higher inflammatory and adaptive immune responses than males as well as how immune responses to infection or vaccination change during pregnancy and over the life course.
Vom Steeg LG, Vermillion MS, Hall OJ, Alam O, McFarland R, Chen H, Zirkin B, Klein SL. Age and testosterone mediate influenza pathogenesis in male mice. Am J Physiol Lung Cell Mol Physiol. 2016 PubMed PMID: 27815260.
Hall OJ, Limjunyawong N, Vermillion MS, Robinson DP, Wohlgemuth N, Pekosz A, Mitzner W, Klein SL. Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females. PLoS Pathog. 2016 PubMed PMID: 27631986.
Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016 PubMed PMID: 27546235.
Klein SL, Shann F, Moss WJ, Benn CS, Aaby P. RTS,S Malaria Vaccine and Increased Mortality in Girls. MBio. 2016 PubMed PMID: 27118593.
vom Steeg LG, Klein SL. SeXX Matters in Infectious Disease Pathogenesis. PLoS Pathog. 2016 PubMed PMID: 26891052.