Bloomberg Distinguished Professor of Biology & Genetics

Molecular Biology and Genetics Department, School of Medicine
Biology Department, School of Arts and Sciences
Director, Molecular Biology and Genetics Department

RESEARCH OVERVIEW

The ribosome is a complex molecular machine that translates the genetic code into functional polypeptides. Our research focuses on understanding how the ribosome functions at a molecular level and how changes in its activity lead to mRNA quality control and the induction of cellular stress responses. Work in the Green lab ranges widely in scope, from detailed mechanistic questions in ribosome rescue to surveying global changes in gene expression and dissecting the complex interplay of mammalian signaling pathways. We use a wide range of genetic, genomic, and biochemical approaches to explore these questions in bacteria, yeast, and increasingly in mammalian systems. Much of our ongoing work focuses on the importance of ribosome collisions in activating signaling pathways such as the integrated stress response (ISR) and various MAP kinase cascades.

Chemical Biology and Proteomics | Genetics, Genomics and Gene Regulation | Translational Research

Selected Publications

Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR. Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria. Nature, 2022.

Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R. Translational repression of NMD targets by GIGYF2 and EIF4E2. PLOS Genetics, 2021.

Goldman DH, Livingston NM, Movsik J, Wu B, Green R. Live-cell imaging reveals kinetic determinants of quality control triggered by ribosome stalling. Molecular Cell, 2021.

Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper W, Bennett EJ, Beckmann R, Green R. EDF1 coordinates cellular responses to ribosome collisions. eLife, 2020.

Wu CC, Peterson A, Zinshteyn B, Regot S, Green R. Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate. Cell, 2020.

Learn more

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