Bloomberg Distinguished Professor
Oncology Department, School of Medicine
Biochemistry and Molecular Biology Department, School of Public Health
RESEARCH OVERVIEW
Research in my laboratory focuses on understanding the cellular and molecular mechanisms that control immune responses, with a particular emphasis on how metabolism governs this process. Currently our work is focused on the role of metabolism in T cell differentiation and function, as well as in regulating other immune cell types, such as macrophages. My laboratory is committed to using a wide variety of approaches to address key questions in immune cell metabolism in vitro and in vivo, and how this impacts protective immunity to infection and cancer. We hope that our work will allow us to develop new ways to target immune cell longevity, differentiation, and function through metabolism, with a long-term goal of mitigating human disease.
Cell Biology | Cellular Stress and Cell Signaling | Immunology and Infectious Diseases
Selected Publications
Edwards-Hicks J, Apostolova P, Buescher JM, Maib H, Stanczak MA, Corrado M, Klein Geltink RI, Maccari ME, Villa M, Carrizo GE, Sanin DE, Baixauli F, Kelly B, Curtis JD, Hassler F, Patterson AE, Field CS, Caputa G, Kyle R, Soballa M, Cha M, Paul H, Martin J, Grzes K, Flachsmann L, Mitterer M, Zhao L, Winkler F, Rafei-Shamsabadi DA, Meiss F, Bengsch B, Zeiser R, Puleston DJ, O’Sullivan D, Pearce EJ, and Pearce EL. Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function. Nature Immunology, 2023.
Baixauli F, Piletic K, Puleston DJ, Villa, M, Field CS, Flachsmann LJ, Quintana A, Rana N, Edwards-Hicks J, Matsushita M, Stanczak M, Grzes K, Kabat A, Fabri M, Caputa G, Kelly B, Corrado M, Musa Y, Duda K, Mittler G, O’Sullivan D, Sesaki H, Jenuwein T, Buescher JM, Pearce EJ, Sanin DE, and Pearce EL. An LKB1-mitochondria axis controls Th17 effector function. Nature, 2022.
Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kamiński MM, Stanckzak M, Weiss HJ, Grzes KM, Piletic K, Field CS, Corrado M, Haessler F, Wang C, Musa Y, Schimmelpfennig L, Flachsmann L, Mittler G, Yosef N, Kuchroo VK, Buescher JM, Balabanov S, Pearce EJ, Green DR, Pearce EL. Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell, 2021.
O'Sullivan D, Stanczak MA, Villa M, Uhl FM, Corrado M, Klein Geltink RI, Sanin DE, Apostolova P, Rana N, Edwards-Hicks J, Grzes KM, Kabat AM, Kyle RL, Fabri M, Curtis JD, Buck MD, Patterson AE, Regina A, Field CS, Baixauli F, Puleston DJ, Pearce EJ, Zeiser R, Pearce EL. Fever supports CD8+ effector T cell responses by promoting mitochondrial translation. PNAS, 2021.
Kelly B, Carrizo GE, Edwards-Hicks J, Sanin DE, Stanczak MA, Priesnitz C, Flachsmann LJ, Curtis JD, Mittler G, Musa Y, Becker T, Buescher JM, Pearce EL. Sulfur sequestration promotes multicellularity during nutrient limitation. Nature, 2021.